> Cryogenics and wormholes are the two best future options

I'd argue that there's a third option that's far better understood and has already been mentioned a few times. Biological immortality. If we can find solutions to problems like aging and disease, problems we're currently researching and resolving, it raises the real possibility that human lifespans could be extended on a near-perpetual basis. Yes, there are a lot of hurdles to overcome, but there's no reason why human lifespans couldn't reach 100,000+ years at some point in the distant future. Fix the problems that kill us, and figure out how to replace the parts that wear out.

Spending 2,500 years transiting to another star system isn't such a big deal if you've got a projected lifespan of 80,000 years.