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Common_Screen9450 t1_ixva78i wrote

Isn’t vaccine the wrong word? I thought vaccines prevented illness that you don’t yet have. Seems like everyone getting this treatment already has GBM.

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ghkbrew t1_ixvbz4s wrote

A vaccine is a substance you give to stimulate an immune response against something else. Even traditional anti-virus vaccines aren't always given before disease exposure. E.g. rabies vaccines are almost always given after exposure. Typically after the 10 days of watching the possibly rabid animal that just bit you to see if it really had rabies.

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unripenedboyparts t1_ixvf6aj wrote

Rabies given after exposure, but before disease. So that is still prophylaxis.

Edit: This is a small point and I'm not disagreeing with you overall.

Edit 2: Geez, I cannot type today. "Rabies after exposure, but before disease. Me Tarzan."

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PM_ME_YIFF_PICS t1_ixvnjk9 wrote

You can always get it before, but getting it after a possible infecting event is definitely a good idea too

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Cold_Turkey_Cutlet t1_ixx632a wrote

>Typically after the 10 days of watching the possibly rabid animal that just bit you to see if it really had rabies.

Wait wut? I don't think this is typical. That would require a captive animal... I suspect most people who got bit by a wild animal or stray dog or something don't end up with the animal in their possession or any opportunity to watch it for 10 days.

But it is an interesting idea if possible. Because apparently the rabies vaccine is horrible and not something you want to go through if you don't need to. Then again, I'm not sure I would want to sit there for 10 days taking my chances with actual rabies either, because if you don't take the vaccine by the time symptoms set in, you're gonna die a horrible painful death.

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ghkbrew t1_iy0ivn0 wrote

You should go with what your local health department says, but yes a 10 day quarantine of the offending animal before starting prophylaxis is standard practice. At least for domestic animals. Wild animals are usually put down for testing if they're available I believe.

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Aeonoris t1_ixvchjl wrote

> I thought vaccines prevented illness that you don’t yet have.

That's a "prophylactic" vaccine. There are also "therapeutic" vaccines, which train your body to fight a disease you already have.

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Cold_Turkey_Cutlet t1_ixx5ixp wrote

First mRNA and now this?? I ain't taken none of them new fangled therapeutic vaccines! I want a traditional, Christian vaccine only!

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Pinky-and-da-Brain t1_ixvke8w wrote

There is a newish thought in the cancer space that cancers like glioblastoma trigger your immune system in a very similar way to an infection so we should fight cancer like an infection. Also, this therapy trains dendritic cells (an immune cell type) to fight cancer which is what vaccines for viruses do (vaccines train immune cells). This “vaccine” is more of a personalized cell therapy than a traditional vaccine that you are thinking about but the name isn’t inaccurate.

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H2AK119ub t1_ixvvqe3 wrote

This is not a new thought...the field of Immuno-Oncology has been around for decades.

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Pinky-and-da-Brain t1_ixvxuvt wrote

I didn’t say immuno oncology is a new thought, I said treating cancer like an infection and creating therapies that target specific cancer is a newish thought. Your immune system remembers and targets infection with very high specificity, that is not true for cancer. Most cancer therapies over the decades have been either broad acting chemotherapies or drugs to increase tumor penetrating T cells (think pd-1 and the like). Training the immune system on specific cancers (personalized cancer therapy) like described in the article is new. These therapies are known as Car-T, dendritic cell therapies (what this article is about), as well as newer NK cell therapies. Dendritic cel therapy(cancer vaccines) require you to take a tumor biopsy, sequence the antigen, train the dendritic cell taken from the patient in a lab on that antigen/s, ensure antigen expression, and then replant the dendritic cells into the patient. That is innovative as it imitates the immune systems response to infection. Source: I worked in immune oncology for years…

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bilyl t1_ixvsbzk wrote

There are therapeutic vaccines and prophylactic vaccines.

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Probably_a_Shitpost t1_ixxl1bb wrote

I used to put these exact vaccines together around 11 years ago. To get this vaccine, you had to have a had the cancer to begin with. A piece of the tumor is taken and combined with cells that will present a specific marker after. Ideally preventing reoccurrence by showing your body that it should attack any cells that present the marker ie. Cancer.

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