I look for a mainline show -- hopefully something I choose as my "Sunday Night" show even if I don't watch it on Sundays.

Usually that has to be something I've been hearing/reading a lot of buzz about, and then the first episode has to hook me. 9 times out of 10 that one will be a Drama. I try to have another drama or two to bounce back and forth at the same time, and two or three comedies for when I need a break. I generally will binge comedies on my off days and save the serious stuff for the hour or two I get to myself when I get off work.

I save stuff like Anime or a show I need to catch up on for vacations when I can devote a ton of time to binge watching.