Westworld is the most confusing in a bad way.

Dark is the most confusing in a good way.

Twin Peaks original run is weird but not really that confusing, season 3 is definitely more abstract, but it also doesn't really try to explain a lot of things, so it might fall more into the ambiguous/open to interpretation category.

1899 isn't confusing partially because they don't reveal the twist but tease things for the entire season, and I don't think the reveal is interesting enough to take a whole season to set up, though with the way it ends I could see a season 2 being a lot more interesting depending the direction it goes.

Game of Thrones isn't confusing or ambiguous at all, but you do have to keep track of a decent number of characters. The Wire would be even another level in terms of the pure number of characters and storylines you need to keep track of.

I only saw a few episodes of Lost and The Prisoner, I remember enjoying Lost and thought The Prison was boring as shit, partially because I had no idea what was going on.

I only saw an episode of Mindhunter but it seems pretty straightfoward.

Monty Python is probably confusing because its an absurdist comedy, but it's supposed to be funny so it is what it is.