For all of my early life, I got super pruney when my hands got wet. Bathing, swimming, doing dishes, etc. Much moreso than the rest of my family or my friends. And it stayed that way for a long time afterwards and felt funny.

Then at age 30, I was diagnosed and treated for diabetes, and suddenly the hand pruniness went completely away. I only get it at a very small level now.

It's one of a ton of improvements to my skin that I saw after I started being treated.