AimlessZealot t1_jdnj41u wrote

I don't spend a lot of time on genetics but as I remember it:

Compartment A weakening- Active chromosomes being weakened.

A/B mixing - Inactive and active chromosomes coming in contact and potentially affecting each other when they are supposed to be kept in separate compartments to avoid that.

Intra-TAD contact - Genes that exist to help enhance, promote or silence specific other genes can affect genes they were not intended to, thanks to the isolating boundaries being broken.

Decreased H3K27ac modification - (This one I kinda remember) This reduces the likelihood of DNA correctly copying sections when signalled (enhanced) and causes some genes to not be enhanced. This is a problem because sections like our opposable thumbs and brain development have been linked to enhancer genes doing their thing, of which many depend on H3K27AC modification to help.

Hope that helps.


AimlessZealot t1_j989n6g wrote

No, that's exactly what you're saying. They stated it was vague because "it had to be," implying repercussions if they were too identifiable. The nature and purpose of whisper networks (which operate exclusively through gossip) is to allow important information and warnings to spread without such dangers.

By insisting that only those who can make clear accusations ever speak of issues, you are also stating anyone who faces jeopardy should either accept additional risks or not bother trying to pass any information. The worst this person's statement could lead to is others watching critically for a reason why or investigating further. That's a good thing, I think.