FourDimensionalTaco t1_jdtlg93 wrote

My problem with this article is that it makes it seem as if attraction towards trans women must always come with misogyny and objectification , which is not the case. You can find mtf women attractive without wanting to dominate them in that toxic manner or reducing them to their genitals.


FourDimensionalTaco t1_j1jhhii wrote

All it takes is for one business to come up with a cure to disrupt the market. If there's a cure, why opt for the ongoing treatment? Such a company will sell the cure for a very high price. Insurers still go for that cure. Maybe not in all cases, but at least the more problematic patients will get it. That company then has a big ace up their sleeve with that cure, and of course patents the hell out of it. Other companies try to come up with their cures so they get picked by insurers. In the meantime, the first company has its monopoly. Once that has run its course, and competitors are coming up with their cures, the first company drops their price massively to undercut the competition.

Diabetes treatment is very expensive for health insurance providers. A cure would be cheaper for them even if it costs 500k once.

And yes, cures are being made for diseases. See this for example. Another example is the ongoing research into growing islets out of stem cells and transplanting said islets. See the Vertex VX-880 trial for example.


FourDimensionalTaco t1_j1jgc9z wrote

Hell no. You completely miss the physiological aspect of this. The sensor filament that has all kinds of special coating to ward off filament degradation and to deal with other phenomena like what happens in the insertion site immediately post-insertion (which is a micro trauma, and the body reacts accordingly). You also miss how electronics in the mid 2000s was far less sophisticated. Creating a CGM transmitter that filters out sensor errors, performs extrapolations, temperature compensation (since the glucose-oxidase enzyme in sensor filaments is highly temperature sensitive), regularly communicates over radio the last N data points, AND can run off a small coin battery for over 90 days was just not doable. I also highly doubt that your makeshift CGM would have anywhere near the same MARD that a G6 has. And with bad MARD your CGM is near useless.

The one area where I agree is the combination of CGM and pump. That's why the WeAreNotWaiting movement exists. That is why projects like AndroidAPS and iOS loop exist. But your own CGM? Not going to happen. No way.


FourDimensionalTaco t1_j1hsd6i wrote

I see a common problem with reports like this one: they do not take the time in range (TIR) metric into account. Especially closed loop systems reduce both hypers and hypos, which is clearly a big improvement. But because the hba1c has the characteristic of an average value, reductions in both high and low blood sugars cancel each other out, and the hba1c remains largely unchanged. Admittedly, this is not relevant if the hba1c is something like 11%, because that is far too high no matter what. But someone with 7% can experience such an improvement in glycemic stability and still remain at 7% for example.


FourDimensionalTaco t1_j1hrvf7 wrote

No. Diabetes is just extremely complicated to fix. Type 1 diabetes is an autoimmune disease and requires fixing the immune response (which is several Nobel prizes away) and restoring the destroyed beta cells. Type 2 diabetes is more of an umbrella term for various types of insulin resistance and associated metabolic problems, and thus also extremely complex. A cure for either type would be immediately be sought after by health care insurance companies, since for them, this would be far more economical than the ongoing expenses for insulin and anticipated diabetic medication.


FourDimensionalTaco t1_j1hrjcx wrote

Disagree. I myself have type 1 diabetes, and CGMs are total game changers. Maybe they are not as useful for many type 2 diabetics, but for type 1, CGMs are essential. Also, I would never trade my pump and ultra rapid Lyumjev insulin for syringes and R. And what closed loop systems can already do is amazing.