Cholesterol builds up where it shouldn’t AND does go where it is needed to make nerve sheath, if I’m reading correctly. So isn’t something still needed to redirect the cholesterol where it needs to go, not just to reduce overall cholesterol?

> Diet and exercise may dramatically alter both gene expression and the effect of a product secreted into a vastly different environment.

This is the basic idea I’m interested in. So there is evidence that diet and exercise can affect the expression of genes like this? Maybe not for this specific gene but do you know of an example where a genetic defect is controlled or put in remission without other therapies?

You have this APOE4 gene? I understand lifestyle can affect all sorts of molecule levels throughout the body, but I’m curious if they are known to affect gene expression like the one this study identified.

If the issue is that cholesterol is not channeled where it can be made in myelin sheath then the problem isn’t too much cholesterol, its that the cholesterol is being sequestered in the wrong place. The effects of lifestyle changes will not eradicate that problem and an argument that diet and exercise are better than medication may be flawed. I’m a layman, just trying to understand the publication.

Can you diet and exercise your way out of a gene that causes cholesterol management problems?