Loose_Asparagus5690

Loose_Asparagus5690 t1_iupb2s5 wrote

In this case, faster is better though. Let's assume that your body needs X amount of the active ingredient in blood to induce the desired effect - which called the therapeutic concentration. While both the gelcap and tablet release the same amount of drug over time. The tablet may takes too long it wouldn't even reach your body's therapeutic concentration, since your liver enzymes would break it down fast enough to keep the drug concentration down. The gelcap, on the other hand, release the drug fast enough to overwhelm the breakdown rate of drug in your body, which raised the drug concentration above the therapeutic concentration, thus induce the desired effect - tinnitus gone.

You can look at graph 2.6 in this link to have a better visualisation. The green line would represent the plasma concentration released by the gelcap and the red line would resemble the tablet.https://www.pharmacy180.com/article/bioavailability-847/

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Loose_Asparagus5690 t1_iuljzpw wrote

Oh, if the gelcap has Diphendydramine HCl then it's not the case about the active ingredient but the delivery form.
When you take an immediate-release tablet, it usually takes 45-60 minutes to slowly disintergrate and release >75% of the active ingredient. That is "immediate" but still slow compare to softgel capsule.
Once a softgel's shell break down, probably in 10-15 minutes, it'll release all of the lipophilic content inside. The content is almost always lipophilic because water would breakdown gelatin. As I said before, lipophilic stuffs absorb better via GI tract (especially at the small colon), so not only the softgel release it content faster, the content itself would absorbs faster. This result in the faster peak of active ingredient concentration in blood. I think that's the reason why it feels better for OP to use the softgel form.

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Loose_Asparagus5690 t1_iulikah wrote

Idk about the CBD because the isn't many studies on its phamacology effects. But "buy the pure isolate and vape that" is a smart move to avoid dodgy products. Just be aware of the dosage.
I found this on mayoclinic: "Currently, the only CBD product approved by the Food and Drug Administration is a prescription oil called Epidiolex". You can look into this product to estimate a safe medicinal dosage.

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Loose_Asparagus5690 t1_iulh7b6 wrote

and the tablet/pill?
I don't live in the US to be familiar with walmart products. If anything I need the name so I could see it's formulation, which has to do with the BA.
My first guess is the active ingredient used in the gelcap is lipophilic so it absorbs faster and can easily get through the blood-brain barrier to the active location. Whereas the one used in the tablet/pill is hydrophilic salt, so it takes a little longer to metabolise to the active form.

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Loose_Asparagus5690 t1_iuleoiw wrote

Here is a link on why Benadryl works.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/
"Antihistamines act by competitively inhibiting peripheral and central histamine receptors. Antihistamines contribute to the treatment of factors affecting the onset of tinnitus. For example, their drying effect improves the functions of the auditory tubes, reduces the accumulation of effusions in the middle ear, and enhances ventilation in the tympanic cavities."

About the gelcap has double the effect of tablet & pill, I'm gonna need more info (generic/brand name).

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