MaximilianKohler OP t1_jbtahqw wrote

Chronic disease of all kinds has been increasing since the advent of antibiotics. Martin Blaser is a leader in the field and recently released a documentary called "The invisible extinction" about this.


MaximilianKohler OP t1_jbpfxtg wrote

I agree that FMT holds great potential, but it needs more research. How to select a safe and effective donor is unknown still. I've been trying to figure it out, and after screening 100k applicants I tried the #1 ranked donor and got worse.

It would be nice if other research groups would pair up with me to help try to figure out the donor quality puzzle.


MaximilianKohler t1_j8adpqi wrote

It can be pretty annoying and harmful for people to confidently spread misinformation.

Possibly we need even more of "debunking with a citation and insult" so people will stop overconfidently spreading misinformation.


MaximilianKohler t1_j8acuco wrote

There is nothing misleading about the title or the documentary. There have been numerous studies showing the gut microbiome to be causative. ASU did an FMT study and the patients improved significantly.

Your comment is far more misleading.


MaximilianKohler OP t1_j1t4drx wrote

Yep. There is a lot to still figure out with FMT. Most studies have severe deficiencies in donor quality and treatment length. Completely replacing an existing and very complex ecosystem isn't simple.


MaximilianKohler OP t1_j1r1u6d wrote

There is a lot to still figure out with FMT. Most studies have severe deficiencies in donor quality and treatment length. Completely replacing an existing and very complex ecosystem isn't simple.


MaximilianKohler OP t1_j1r1nta wrote

Most of that is not true. There's a wiki stickied in my profile that has a page on Aging, which debunks much of those claims. The "Intro" and "FMT" pages also have many studies showing long-term benefits.

There is a bi-directional pathway where environment can affect the microbiome and vice versa. But most studies show that the symptoms stem from the changing of the gut microbiome, and restoring it via FMT can reverse symptoms. Changing environment is much more limited, which is why FMT is being heavily researched as a treatment for numerous conditions.

There are many factors that need to be figured out, such as identifying ideal donors, and methods to completely replace the existing microbiome.

Our gut microbiomes have evolved alongside us for a millenia, and get passed down generationally. We're doing significant, permanent damage via antibiotics, lack of breastfeeding, junk diets, and more And these extinctions may only be reversible with FMT from the few people who are not yet damaged.


MaximilianKohler OP t1_j1qt9jx wrote

> Background > > Aging is a natural process that an organism gradually loses its physical fitness and functionality. Great efforts have been made to understand and intervene in this deteriorating process. The gut microbiota affects host physiology, and dysbiosis of the microbial community often underlies the pathogenesis of host disorders. The commensal microbiota also changes with aging; however, the interplay between the microbiota and host aging remains largely unexplored. Here, we systematically examined the ameliorating effects of the gut microbiota derived from the young on the physiology and phenotypes of the aged. > > Results > > As the fecal microbiota was transplanted from young mice at 5 weeks after birth into 12-month-old ones, the thickness of the muscle fiber and grip strength were increased, and the water retention ability of the skin was enhanced with thickened stratum corneum. Muscle thickness was also marginally increased in 25-month-old mice after transferring the gut microbiota from the young. Bacteria enriched in 12-month-old mice that received the young-derived microbiota significantly correlated with the improved host fitness and altered gene expression. In the dermis of these mice, transcription of Dbn1 was most upregulated and DBN1-expressing cells increased twice. Dbn1-heterozygous mice exhibited impaired skin barrier function and hydration. > > Conclusions > > We revealed that the young-derived gut microbiota rejuvenates the physical fitness of the aged by altering the microbial composition of the gut and gene expression in muscle and skin. Dbn1, for the first time, was found to be induced by the young microbiota and to modulate skin hydration. Our results provide solid evidence that the gut microbiota from the young improves the vitality of the aged.