High uric acid is likely from eating fructose.

Yeah but I wonder if they looked at or had a population that was say only eating animal products without any of the junk food listed above, and if that would have similar risk reductions. I looked at the food intake in the pdf and animal foods were higher in those who ate the most junk food. However they used a plant based health score and didn't make a model where meat could be healthy.

Plant-based diets are considered to be beneficial for planetary health.7,37 In addition, healthful PBDs are largely compatible with dietary recommendations for the prevention of chronic diseases across the globe,38 including those for a planetary health diet by the EAT-Lancet Commission on Food, Planet, Health.39 Our results provide further evidence to substantiate that PBD quality may be essential for individual health—that is, that PBDs are not beneficial per se and can even be detrimental to health depending on their composition. Interestingly, although we observed that the hPDI was associated with a lower risk of mortality, CVD, and cancer, we found no associations with hemorrhagic stroke and fracture. The latter have been reported to be more common among participants in the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Oxford cohort who consumed a vegetarian or vegan diet,40,41 who have otherwise lower cardiometabolic disease risk.42 Our findings suggest that a healthful flexitarian type of PBD including lower amounts of animal foods may protect against such potential adverse effects of vegan or vegetarian diets.

International scientists, including an Australian, looked at health records for more than 125,000 people in the UK, and found a healthy vegan diet was linked to lower risk of heart disease, cancer and premature death, compared with non-vegan diets. However, vegans who drank more sugary drinks and fruit juices, and ate more snacks, desserts, refined grains and potatoes had a higher risk of these conditions and premature death than non-vegans. Although this type of study cannot show a healthy vegan diet actually caused the improvements in health outcomes, the authors recommend people concerned about chronic disease adopt a plant-based diet that's low in animal products, sugary drinks, snacks and desserts, refined grains, potatoes, and fruit juices.

Hmm so omnivore eating refined grains and sugar probably has the same issues. Not really sure what this has to do with meat consumption.

Can't find full text

Abstract
Multiple dietary patterns have been associated with different diseases; however, their comparability to improve overall health has yet to be determined. Here, in 205,852 healthcare professionals from three US cohorts followed for up to 32 years, we prospectively assessed two mechanism-based diets and six diets based on dietary recommendations in relation to major chronic disease, defined as a composite outcome of incident major cardiovascular disease (CVD), type 2 diabetes and cancer. We demonstrated that adherence to a healthy diet was generally associated with a lower risk of major chronic disease (hazard ratio (HR) comparing the 90th with the 10th percentile of dietary pattern scores = 0.58–0.80). Participants with low insulinemic (HR = 0.58, 95% confidence interval (CI) = 0.57, 0.60), low inflammatory (HR = 0.61, 95% CI = 0.60, 0.63) or diabetes risk-reducing (HR = 0.70, 95% CI = 0.69, 0.72) diet had the largest risk reduction for incident major CVD, type 2 diabetes and cancer as a composite and individually. Similar findings were observed across gender and diverse ethnic groups. Our results suggest that dietary patterns associated with markers of hyperinsulinemia and inflammation and diabetes development may inform on future dietary guidelines for chronic disease prevention.

Abstract

Asthma is a chronic disease that affects the quality of life of patients, and asthma exacerbations are often a reason for hospitalization and activity limitations. Obesity has been linked to asthma as a risk and exacerbating factor. Evidence suggests that weight reduction has a positive effect on asthma control. However, there is also debate on the role of the ketogenic diet in asthma control. Here we present a case of asthma who reported markedly improved asthma after starting a ketogenic diet in the absence of any other lifestyle change. Over the four months on the ketogenic diet, the patient reported losing 20 kg of weight, reduction in blood pressure (without antihypertensives), and complete alleviation of asthma symptoms. This case report is important as the control of asthma after a ketogenic diet is not studied well in humans and therefore needs to be studied extensively.

Keywords: asthma; case report; control; ketogenic diet; management.

It's epidemiology so not really.

We should also note that this is in Finland I believe.

OHS Defined:

Using Statistical Analysis System version 9.4, we combined the binary variable of brushing daily 1/0 and flossing daily 1/0, and categorised the cohort into four mutually exclusive groups: group 0 consisted of those who never brushed or flossed; group 1 consisted of those who flossed but not brushed; group 2 consisted of those who brushed but not flossed; and group 3 consisted of those who brushed daily and flossed. There were only four people in group 1 and we merged them into group 0. Thus, OHS group 0, 1 and 2 were created: 0 being the poorest oral hygiene group (poor OHS and reference); 1 being those who brushed daily but not flossed (good OHS); and 2 being those who brushed and flossed (better OHS). Because the sample size in Cox regression is event rate (that is, CVD mortality), the sample size in this study is very small between 40-50. Thus, to save the degree of freedom (statistical power), we used linear trend models whenever possible. Combining people who never brushed and brushed seldom led to the reference group (n = 41). Next, we generated two levels of OHS, namely, who only brushed daily (n = 261) (OHS level 1) and the 57 people who brushed and flossed became OHS level 2. The baseline characteristics were stratified by OHS categories and compared by non-parametric three-group comparison by Kruskal-Wallis test or chi-squared test.

Published: 03 February 2023 Oral hygiene, mouthwash usage and cardiovascular mortality during 18.8 years of follow-up

Sok-Ja Janket, Caitlyn Lee, …Jukka H. Meurman Show authors British Dental Journal (2023)Cite this article

6101 Accesses 280 Altmetric

Abstract

Aim(s) We tested the following hypotheses: would better oral hygiene self-care (OHS) influence cardiovascular (CVD) mortality? Will using mouthwash in addition to OHS affect CVD mortality? How does mouthwash usage impact the oral microbes?

Design and methods Among 354 dentate subjects from the Kuopio Oral Health and Heart study, the association of OHS with CVD mortality was assessed using Cox regression analyses, adjusting for age, sex, smoking, dyslipidemia, diabetes, hypertension and education. Additionally, whether using mouthwash would affect this relationship was evaluated.

Results In the multivariable-adjusted models, OHS was associated with a 51% reduction in the risk of CVD mortality (hazard ratio [HR] 0.49 [0.28-0.85]; p = 0.01). Even those who had coronary artery disease at baseline showed a marginally significant benefit (0.50 [0.24-1.06]; p = 0.07). However, mouthwash usage did not change OHS effects (HR = 0.49 [0.27-0.87]; p = 0.01), indicating no additional benefits nor detriments. All tested microbes trended to decrease with mouthwash usage in the short term, but none were statistically significant.

Conclusion Good OHS significantly lowered the risk of CVD mortality relative to poor OHS. Mouthwash usage did not show any long-term harm or benefit on CVD mortality beyond the benefits rendered by brushing and flossing.

Key points Good oral hygiene self-care (OHS) that encompasses both brushing and flossing was associated with significantly lower risk of cardiovascular mortality compared with poor OHS during a median follow-up of 18.8 years.

The patients who had coronary artery disease at baseline also experienced a marginally significant decrease in the risk of cardiovascular mortality with good OHS (p = 0.07).

The additional use of mouthwash with OHS did not influence the risk of cardiovascular mortality.

Abstract

The consumption of isoflavones is gaining popularity worldwide due to their beneficial effects on health. However, isoflavones are considered to be endocrine disruptors and cause deleterious effects on hormone-sensitive organs, especially in males. Therefore, this study aimed to determine if a continuous and prolonged exposure to isoflavones in adult males altered the endocrine axis effect of testicular function. For this purpose, seventy-five adult male rats were administered with low and high mixtures of isoflavones (genistein and daidzein) for 5 months. The determination of steroid hormones (progesterone, androstenedione, dehydroepiandrosterone, testosterone, dihydrotestosterone, 17β-estradiol, and estrone sulphate) was carried out in serum and testicular homogenate samples. Sperm quality parameters and testicular histology were also determined. The results revealed that low and high doses of isoflavones promote a hormonal imbalance in androgen and estrogen production, resulting in a decrease in circulating and testicular androgen levels and an increase in estrogen levels. These results are associated with a reduction in the sperm quality parameters and a reduction in the testicular weight, both in the diameter of the seminiferous tubules and the height of the germinal epithelium. Altogether, these results suggest that a continuous exposure to isoflavones in adult male rats causes a hormonal imbalance in the testes that disrupts the endocrine axis, causing defects in testicular function.

Introduction Genistein is an isoflavone phytoestrogen that induces cell differentiation in tissue culture Constantinou and Huberman (1995). An inhibitor of tyrosine kinase, histidine kinase, and topoisomerase Akiyama et al (1987), Huang et al (1992), Barnes and Petersen (1995), genistein is thought to be an anticancer, antiproliferative, cardioprotective and/or chemopreventive agent. It is possible, however, that the enzyme inhibitory effects may only occur at non-physiological concentrations Belenky et al (2003). At physiological concentrations, genistein activates the nuclear estrogen receptors ER-alpha and ER-beta Kuiper et al (1997), Kuiper et al (1998), Casanova et al (1999) and affects TGF-beta signaling pathways Kim et al (1998). While genistein, or its more soluble glucoside derivative genistin, are taken as a dietary supplement, they have not been thoroughly tested in clinical trials. Common dietary supplements often include other isoflavones, such as daidzein and glycitein or their corresponding glucoside conjugates.

A la pemmican

What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss http://orcid.org/0000-0002-9950-254XDavid Unwin1,2, http://orcid.org/0000-0001-5163-1716Christine Delon3, Jen Unwin4, Simon Tobin4 and Roy Taylor5 Correspondence to Dr David Unwin; unwin5@btinternet.com Abstract

Background Type 2 diabetes (T2D) is often regarded as a progressive, lifelong disease requiring an increasing number of drugs. Sustained remission of T2D is now well established, but is not yet routinely practised. Norwood surgery has used a low-carbohydrate programme aiming to achieve remission since 2013.

Methods Advice on a lower carbohydrate diet and weight loss was offered routinely to people with T2D between 2013 and 2021, in a suburban practice with 9800 patients. Conventional ‘one-to-one’ GP consultations were used, supplemented by group consultations and personal phone calls as necessary. Those interested in participating were computer coded for ongoing audit to compare ‘baseline’ with ‘latest follow-up’ for relevant parameters.

Results The cohort who chose the low-carbohydrate approach (n=186) equalled 39% of the practice T2D register. After an average of 33 months median (IQR) weight fell from 97 (84–109) to 86 (76–99) kg, giving a mean (SD) weight loss of −10 (8.9)kg. Median (IQR) HbA1c fell from 63 (54–80) to 46 (42–53) mmol/mol. Remission of diabetes was achieved in 77% with T2D duration less than 1 year, falling to 20% for duration greater than 15 years. Overall, remission was achieved in 51% of the cohort. Mean LDL cholesterol decreased by 0.5 mmol/L, mean triglyceride by 0.9 mmol/L and mean systolic blood pressure by 12 mm Hg. There were major prescribing savings; average Norwood surgery spend was £4.94 per patient per year on drugs for diabetes compared with £11.30 for local practices. In the year ending January 2022, Norwood surgery spent £68 353 per year less than the area average.

Conclusions A practical primary care-based method to achieve remission of T2D is described. A low-carbohydrate diet-based approach was able to achieve major weight loss with substantial health and financial benefit. It resulted in 20% of the entire practice T2D population achieving remission. It appears that T2D duration <1 year represents an important window of opportunity for achieving drug-free remission of diabetes. The approach can also give hope to those with poorly controlled T2D who may not achieve remission, this group had the greatest improvements in diabetic control as represented by HbA1c.