Pr0gr3s t1_j5rune7 wrote

He probably had familial Alzheimer's, which is genetic and can occur much younger. We understand fAD pretty well, although that doesn't mean we can doing anything.

This article is talking about sporadic AD, which is around 95pct of cases.


Pr0gr3s t1_j0ph8te wrote

This is an old and thoroughly disproven concept that wont seem to die. The brain is absolutely responsive to insulin. GLUT4 is highly expressed in some parts of the brain and requires insulin binding to translocate from storage vehicles to the plasma membrane. Hippocampal memory gets a lot of focus in this regard, which dovetails into Alzheimer's.


Pr0gr3s t1_iwnxqdq wrote

45 is actually a decent N for a RCT with a within subjects design. The design increases statistical power significantly over a between subjects design, which is likely what you are picturing.