PyroDesu t1_j943lbx wrote


PyroDesu t1_j1nxrx1 wrote

Security questions are pretty much always about easily looked up facts. Social media has rendered them non-secure if they're used as intended.

(I personally put "answers" that are the same alphanumeric-symbolic garbage as my passwords, and save them in the notes section of my password manager entry.)


PyroDesu t1_izjb20k wrote

Not true!

Sun (or more specifically, UV-B) exposure only generates the inactive cholecalciferol, the same stuff you can get from diet (diet can also give you ergocalciferol, the plant-based version, which works too). The activation process is two enzyme hydroxylation steps, first in the liver and second in the kidneys.


PyroDesu t1_iu7rkq1 wrote

> The pathogenic form of tau is the hyperphosphorylated version, where tau carries more phosphate groups (negatively charged) allowing it to stick to each other and form what we call neurofibrillary tangles inside a neuron.

What causes the hyperphosphorylation, out of curiosity?