Rain_Dont_Pour

Rain_Dont_Pour OP t1_jb625w7 wrote

Reply to comment by HeTakesYou in Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

I'm not sure, I think everyone should receive treatment independently of their follistatin levels. I believe what they're trying to show is that having the high levels of the protein promotes chemoresistance.

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Rain_Dont_Pour OP t1_jb61xm4 wrote

Reply to comment by Economy_Appearance_9 in Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

I think this is a hard question to respond since they didn't look into that mechanism, I believe the pathways of resistance are different, but maybe there could be a connection between both.

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Rain_Dont_Pour OP t1_jb61qjr wrote

Reply to comment by damnan99 in Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

I believe what they're trying to say is that you would have to create an antibody that would block the action of follistatin so it doesn't bind to the receptor. I think the concept of lowering the levels of follistatin is not feasible, but it could be a possibility that the authors haven't looked into.

From my understanding, they were able to create cells that didn't produce follistatin and that's how they proved that absence of it made ovarian cancer cells more sensitive to chemo.

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Rain_Dont_Pour OP t1_jb50wox wrote

Reply to Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2254/716616/Quiescent-ovarian-cancer-cells-secrete-follistatin?redirectedFrom=fulltext

DOI: https://doi.org/10.1158/1078-0432.CCR-22-2254

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