Roguewolfe
Roguewolfe t1_jdegqw0 wrote
Reply to comment by TackingIntoTheWind in TIL that the Hemlock Water Dropwort is the most poisonous plant in the UK. Its poison constricts the muscles, causing death by asphyxia, which also causes a rictus like death grin. Use of this plant in Phoenician Sardinia for executions is the origin of the term "Sardonic Grin". by AspireAgain
It's exactly like that. Quite a few nasty things can cause that type of spastic paralysis (defined as paralysis where muscles cannot relax or un-flex: it's the opposite of flaccid paralysis where they cannot flex).
Your brain, nerves, and muscles have an interconnected system bridged by a small physical gap called the neuromuscular junction. This tiny gap has neurotransmitters that flow between a motor neuron and a muscle. First, your brain decides you want to move or make a motion of some sort, and communicates that to the cerebellum, which subconsciously coordinates the movement (because all movements are quite a bit more complicated and involve more muscles than we realize consciously). Next, the cerebellum, via the spinal cord, sends a message to the muscles saying, "flex!" That message is communicated via a small messenger molecule, acetylcholine. When we no longer wish to flex, we both stop emitting acetylcholine and we actively destroy and recycle any acetylcholine remaining in the junction using enzymes (acetylcholinesterase iirc).
Things that cause paralysis (other than brain and spinal cord injuries) interrupt this process in some way. Things that cause spastic paralysis either mimic acetylcholine but don't get destroyed by enzymes so they stick around for a long time, or they do it by preventing enzymes from finding and reacting with acetylcholine. In the latter example, they usually bind to the enzymes themselves, and "plug it up". In the former example, they bind to the acetylcholine receptor on the muscle cell, activating it and also "plugging it up" such that it stays turned on regardless of what our brain is trying to tell it.
You could also cause flaccid paralysis by disrupting the release of acetylcholine, or by plugging up the muscle receptor with a molecule that binds to it but does not activate it, similar to but critically different from the spastic example in how it affects the cell's interior.
There's quite a lot of plant and insect toxins that can do one or the other. Curare is an often used example in undergraduate biology.
Roguewolfe t1_jbg0c1t wrote
Reply to comment by PLEASE_STOP_it_hurts in WIRED computer mouse. I'm particularly interested in one with a cable that will not fray. They seem to fray very shortly after I get them. I want the cable to be like a quarter of an inch thick. I don't care if the thing weighs 5 lbs. My budget is $200. by TheJawsofIce
shrug
Agree to disagree, I guess. Any amount of unnecessary load/lag is getting deleted off of my gaming rig.
Edit: Guessing the downvotes are all from people using wireless mice whom are getting farmed constantly
Roguewolfe t1_jbfx3fu wrote
Reply to WIRED computer mouse. I'm particularly interested in one with a cable that will not fray. They seem to fray very shortly after I get them. I want the cable to be like a quarter of an inch thick. I don't care if the thing weighs 5 lbs. My budget is $200. by TheJawsofIce
OP - I share your preference for wired mice, for all of the regular reasons.
May I recommend this to prevent cord fraying: a mouse cable holder. It actually works quite well at preventing fraying, and also slightly reduces overall drag.
Roguewolfe t1_jbfwevx wrote
Reply to comment by barbarapalvinswhore in WIRED computer mouse. I'm particularly interested in one with a cable that will not fray. They seem to fray very shortly after I get them. I want the cable to be like a quarter of an inch thick. I don't care if the thing weighs 5 lbs. My budget is $200. by TheJawsofIce
Because the input latency and CPU load is exponentially lower with a wired mouse. That matters to most people, and to some people matters a lot. I am one of those people. You can make the argument that the load is low, and that's absolutely true, but it's still a load, and there's still additional lag, however little.
Wireless DACs on both sides (transmitter + receiver) introduces an additional processing step to allow the radio signal transmission and decoding. Wired bypasses all of that and requires no digital to analog conversion and back again - it just stays digital the whole time.
There are many situations in which a wireless mouse is better - particularly with laptops, air travel, etc. A gaming rig is not one of those situations, and that's why I prefer wired for that. I use a wireless mouse for work stuff. Other people don't care and use a wireless mouse for everything, and that's ok too.
Edit: lol "tHeRe's LeSs LaG nOW" ok neat, I agree, but there's still lag, everything I said is still true, use whatever mouse you want. Putting a battery in things that don't need it is beyond stupid, though.
Roguewolfe t1_ja97gg0 wrote
Reply to comment by JohnnyOToole in Looking for an automatic pour over style coffee maker that lasts over a year… by aarond9760
Does it bloom and wait before finishing the pot?
How is this functionally different than a standard drip coffeemaker?
Roguewolfe t1_jdi95f0 wrote
Reply to comment by Ladranix in TIL that the Hemlock Water Dropwort is the most poisonous plant in the UK. Its poison constricts the muscles, causing death by asphyxia, which also causes a rictus like death grin. Use of this plant in Phoenician Sardinia for executions is the origin of the term "Sardonic Grin". by AspireAgain
That....that is a fun fact :)