Tagthedog
Tagthedog t1_j992kei wrote
Reply to comment by letmeinmannnnn in Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model (2023) by basmwklz
Helped, High LDL reduced IL-10 which enabled more CD4+T cells to differentiate into central memory-like phenotype - which is essential for prolonged anti-tumor immunity and durable response to checkpoint blockade.
There is a positive correlation between obesity and response to checkpoint blockade, this may be fishing out the reason why.
Tagthedog t1_j9arcay wrote
Reply to comment by letmeinmannnnn in Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model (2023) by basmwklz
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789456
In case you were interested