Xambia t1_iuizjkj wrote on October 31, 2022 at 6:10 PM

Reply to comment by kippypapa in How do white blood cells know in which direction there is a bacteria? by Enocli

Are you asking "Why/how did white blood cells evolve chemotaxis?" or "Why/how did bacteria evolve to release chemoattractants?"

Xambia t1_iuhtjma wrote on October 31, 2022 at 1:21 PM

Reply to comment by tinybabymoose in How do white blood cells know in which direction there is a bacteria? by Enocli

Once the neutrophils make it to the bacteria they follow chemoattractants released from the bacteria (and behave as you see in the video) usually in response to oligopeptides released from the bacteria which have a formyl functional group attached to the N-terminus of the peptide (ex: fMLP)

Edit: I should add that these oligopeptides bind to protein receptors (GPCRs) on the surface of the neutrophil and the location of these activated receptors on its surface let the neutrophil "know" where to go.

Xambia t1_irmledn wrote on October 9, 2022 at 12:36 PM

Reply to comment by dan_dares in Could CRISPR transform a mouse stem cell to a human stem cell? by scrooch

Not to mention the relative expression of these new proteins would likely be off compared to those in a normal human cell. Having the new DNA is one thing, but having the correct epigenetic factors governing gene expression is another issue.