adamredwoods t1_jbig6xq wrote on March 9, 2023 at 7:19 AM Reply to Two-pronged immunotherapy eliminates metastatic breast cancer in mice | Suggests a new approach for treating breast cancers that have spread to bone by chrisdh79 OX40 and p38MAPK inhibitor drugs already exist and used in other trials, so that's a good sign. Not sure what's stopping them from starting? Actual paper: https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-22-0907/716615/p38MAPKa-stromal-reprogramming-sensitizes Associated links: https://www.mycancergenome.org/content/drugs/tavolimab/ https://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases https://pubmed.ncbi.nlm.nih.gov/18776065/ Permalink 1
adamredwoods t1_jbig6xq wrote
Reply to Two-pronged immunotherapy eliminates metastatic breast cancer in mice | Suggests a new approach for treating breast cancers that have spread to bone by chrisdh79
OX40 and p38MAPK inhibitor drugs already exist and used in other trials, so that's a good sign. Not sure what's stopping them from starting?
Actual paper: https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-22-0907/716615/p38MAPKa-stromal-reprogramming-sensitizes
Associated links:
https://www.mycancergenome.org/content/drugs/tavolimab/
https://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases
https://pubmed.ncbi.nlm.nih.gov/18776065/