About $799, down from $1000 just a few years ago I think so depending on your situation it may be prescient to bookmark this and come back to it when the price falls further, just keep in perspective time's effect on the integrity of your genes.

1.) The ultra sequencing I've recommended specifically searches for and reports on individual mutations including both coding and non-coding regions.

2.) DNA, as I assume you meant DNA, is the substrate for epigenetic regulation, and changes in the epigenetic marks on DNA can influence the expression of specific genes and have an impact on an individual's traits and susceptibility to certain diseases. Via high-throughput whole genome NGS, the ultra sequence also provides parsable insight into the epigenome.

Read my reply.

Although the genome is largely static throughout an individual's life, there are a few mechanisms that can lead to changes in the genome. One mechanism is mutation, which is a change in the DNA sequence that can occur as a result of errors during DNA replication or exposure to certain environmental factors, such as radiation (not just the via the likes of Polonium, think UV radiation) or chemicals. Mutations can result in changes to an individual's genetic makeup and can be passed down to future generations.

Another mechanism that can lead to changes in the genome is epigenetic modification, which refers to the process by which certain chemical modifications to DNA or to the proteins that DNA is wrapped around (called histones) can alter the expression of specific genes without changing the underlying DNA sequence. Epigenetic modifications can be influenced by a variety of factors, including diet, stress, and environmental exposures, and they can have an impact on an individual's traits and susceptibility to certain diseases.

So, while the genome is largely static throughout an individual's life, there are mechanisms that can influence it's mutation as you age, thus the recommendation to procure a "save state".

Perhaps, the future holds many unknown unknowns. This is merely insurance in case repairing your genes is costlier or less effective than simply returning your genome to a specific save state.

Rather than an AI guessing what information has been lost as your genes deteriorate with age, it may be simpler and cheaper to just reintroduce an intact version that information.

One of the things you just mentioned, bone loss being impossible, is called osteopetrosis which, although it's origins are complex, is specifically caused by gene expression changes and deterioration in your genome as you age.

You actually can treat DNA like a bodily coding langauge, as it is in fact the instruction manual that every process in your body works off of.

The only reason old cells are "old" is because they are being produced from a damaged, deteriorated, and incomplete genome.

Take puberty for example. The only reason puberty happens is because of the deterioration in a metabolic feedback loop that once broken kicks off the process of puberty through the newly unchecked increase in the production of GnRH in the hypothalamus.

Giving the body's cells fresh, undamaged DNA to work off of is like giving an unripped blueprint to a contractor. All of the parts that were once missing, like for instance stem cell production, are now back in the hands of the systems that build them and the processes that build those systems.

So even if the process may be more complex than currently understood, it's still well worth your while to get your genome sequenced as "insurance" for when full rejuvenation therapies do become viable.

I've actually done this using Nebula's Whole Genome Sequencing services. I recommend everyone do the same and opt for the Ultra Deep test kit. It's much pricier, but far more comprehensive than the other offerings, if for no other reason than they offer a full mapping of your genetic proteome- information which could prove vital for future rejuvenation therapies.

And my recommendation, if you're young or in good health, is to do this sooner rather than later- each day that passes you're a day older and just that much more succepitble to irreversible gene expression changes.

https://portal.nebula.org/register

Idk, I'm pretty satisfied with its answer

Prepare to be shocked

Necessary. Monetary economies will

Lol criticism in a vacuum. What are the alternatives and be practical in your answer.

Yes.

!RemindMe 5 years

I've literally never seen this anywhere on Reddit except in threads warning female travelers about going to places like India or Egypt alone

Throw the Stormlight and Warhammer 40k series in there too

Exactly. People throw out "decades" like it's a salient point when it's really just un-thought through, kneejerk, and "safe" prediction.

Holy fucking shit protein based macromolecular machines are literally the nanobots of the future and with this their existence just became a guaranteed reality. Holy fuck if this can do what I think it can do the world has just been changed AGAIN. One field, biology, utterly revolutionized at least 4 times in one fucking year holy fucking shit.

80 years lol that's conservative. You're forgetting the compounding nature of these technologies. 20 years max before things get to a point of sophistication that our society is unrecognizable from today. And that's worst case scenario. Realistically, considering what guys like Sam Altman and Demis Hassabis have to say about it, the progress thus far and their projections for the near and long term future for where this tech is going to go- we're 5-10 years away from something resembling AGI coming online.

>I’m hoping the elites

Let me stop you right there.

Not as concise as a list of 10-20, but this github repo threading together the most impactful papers leading to our modern conceptualizations of ML as a sort of almost narrative driven pseudo-textbook is immensely useful for getting fully caught up on the modern state of ML, regardless.

That's a good, succinct description. You should add more descriptions.

Can you expound on the primordial black holes point?

I think his point is also that the keyboard itself is more legible