becausenope

becausenope t1_ivgmcmg wrote

I've read that Yersinia pestis, the bacterial pathogen of bubonic plague, does not in fact use the CCR5 receptor for entry.

Would love for someone smarter than I to discuss. Thanks.

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becausenope t1_ivda9bm wrote

I think this might fit the bill.

The CCR5 delta 32 mutation creates resistance to HIV-1. It's found in roughly 10% of European and West Asian populations. https://pubmed.ncbi.nlm.nih.gov/16216086/ While we don't know the exact virus to have caused such a mutation to occur, we do know it was selected for a reason, rapidly and much sooner than we had anticipated. https://pubmed.ncbi.nlm.nih.gov/15815693/ https://pubmed.ncbi.nlm.nih.gov/18790087/

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