Animals treated with indomethacin and celecoxib show a significant decrease in the content of calcium and phosphorus when compared to control group. Treatment also increased carbon, but did not change oxygen content compared to control group. Microhardness test was performed and both treatments reduced the enamel hardness compared to the control group. Regarding to enamel morphology, treatment did not impact enamel thickness and volume, but significantly reduced the mineral density. Visual inspection of the enamel, showed no significant structural or color change.
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Reply to Anti-inflammatory drugs commonly taken by children can cause alterations to dental enamel, study shows by cleanvar
From the study:
Animals treated with indomethacin and celecoxib show a significant decrease in the content of calcium and phosphorus when compared to control group. Treatment also increased carbon, but did not change oxygen content compared to control group. Microhardness test was performed and both treatments reduced the enamel hardness compared to the control group. Regarding to enamel morphology, treatment did not impact enamel thickness and volume, but significantly reduced the mineral density. Visual inspection of the enamel, showed no significant structural or color change.