dissolutewastrel

dissolutewastrel OP t1_j5vzuu4 wrote

Reply to Insulin-regulated serine and lipid metabolism drive peripheral neuropathy by dissolutewastrel

#Abstract

> Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves1,2. Although the onset and progression of these co-morbidities are linked with insulin resistance, hyperglycaemia and dyslipidaemia3,4,5,6,7, aberrant non-essential amino acid (NEAA) metabolism also contributes to the pathogenesis of diabetes8,9,10. Serine and glycine are closely related NEAAs whose levels are consistently reduced in patients with metabolic syndrome10,11,12,13,14, but the mechanistic drivers and downstream consequences of this metabotype remain unclear. Low systemic serine and glycine are also emerging as a hallmark of macular and peripheral nerve disorders, correlating with impaired visual acuity and peripheral neuropathy15,16. Here we demonstrate that aberrant serine homeostasis drives serine and glycine deficiencies in diabetic mice, which can be diagnosed with a serine tolerance test that quantifies serine uptake and disposal. Mimicking these metabolic alterations in young mice by dietary serine or glycine restriction together with high fat intake markedly accelerates the onset of small fibre neuropathy while reducing adiposity. Normalization of serine by dietary supplementation and mitigation of dyslipidaemia with myriocin both alleviate neuropathy in diabetic mice, linking serine-associated peripheral neuropathy to sphingolipid metabolism. These findings identify systemic serine deficiency and dyslipidaemia as novel risk factors for peripheral neuropathy that may be exploited therapeutically.

> Handzlik, M.K., Gengatharan, J.M., Frizzi, K.E. et al. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. Nature (2023).

> https://doi.org/10.1038/s41586-022-05637-6

> Received > 20 December 2021

> Accepted > 07 December 2022

> Published > 25 January 2023

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dissolutewastrel t1_j3f3uso wrote

Reply to [New York Times] Tranq Dope: Animal Sedative Mixed With Fentanyl Brings Fresh Horror to U.S. Drug Zones by Hoyarugby

you wouldn't have to worry about xylazine in your fent if you could just buy hydrocodone at CVS, like maybe with a Chicken Caesar wrap and a pack of Hubba Bubba.

If people were zonked out on Oxy from an orange bottle with pills manufactured by Purdue Pharma, their lives might still be troubled...but not like this.

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dissolutewastrel OP t1_iyw5nh2 wrote

Reply to comment by InTheEndEntropyWins in Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity by dissolutewastrel

Physical activity is definitely good for you. But what's the effect size? Here's a paragraph summarizing some data from the same study:

> All the twin pairs came in for physical examinations, and the results were pretty much what you’d expect. The exercising twins had higher VO2 max (38.6 vs. 33.0 ml/kg/min), smaller waist circumference (34.8 vs. 36.3 inches), lower body fat (19.7 vs. 22.6 percent), significantly less abdominal fat and liver fat, and so on. The study is free to read if you want to dig further into the details, but the results aren’t surprising. Exercise clearly improves a bunch of health parameters, and genes clearly matter too—after all, the differences aren’t that big.

https://www.outsideonline.com/health/training-performance/twin-exercise-research-2022/

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dissolutewastrel OP t1_itepgv6 wrote

Reply to 2nd suspect sought for murders of two teenagers in Pottstown, Pennsylvania by dissolutewastrel

Here's a salient detail that appears in another version of the article

> Kelly, a Philadelphia man, is wanted on two counts of first-degree murder in connection to this shooting. However, officials say he is has eight other outstanding warrants and a bench warrant for aggravated assault, robbery, terroristic threats and related charges in several nearby cities.

https://www.fox29.com/news/da-philadelphia-man-with-8-outstanding-warrants-wanted-for-teen-double-homicide-in-pottstown

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