dude2dudette
dude2dudette t1_iv80mfh wrote
Reply to comment by dangil in BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE. - Biological Psychiatry by chilladipa
The Serotonin Model is probably only accurate for a subset of those with depression.
Depression itself may be a symptom, with multiple possible causes (a bit like how severe stomach pain could be caused by IBS, Crohn's, Endometriosis etc.)
There might be various neurochemical imbalances that each can cause the behavioural/cognitive outcome of 'Depression' (especially given the different subtypes of depression that exist)
dude2dudette t1_ivb3d62 wrote
Reply to comment by Able-Emotion4416 in BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE. - Biological Psychiatry by chilladipa
Behavioural/environmental mechanisms are certainly important. However, that doesn't exclude neurotransmitter mechanisms.
It could be that the environment causes neurotransmitter receptor activation changes (e.g., lived environment (work stress/poor living space/lack of exercise, etc.) modifying one's immune system could lead to opioid activation dysfunction, which could then lead to depressive symptoms - see Charles, Farias and Dunbar, 2020)