Could you tell us a little more about the seasonal modulation of microseismicity? Which seasons?

Thank you, this makes sense to me both in terms of what I understand about the body and also in terms of my own experience. I’d be curious to see data from large scale studies that link sleep to health and sickness.

But that’s just it, we can’t answer the question about the biggest factor that makes an immune system most effective in its specific context. For example an immune system that very effectively fights off viruses and bacteria so that the human is not often sick, but also does not overreact and create auto immune disorders.

I would love to get pointed towards scientific studies or knowledge about which factors have the largest impact, for example between two healthy people, and by healthy I mean in terms of lifestyle, can specific colonizations of good bacteria cause disparities in how their immune system fight off viruses and bacteria? Can this have an impact that is statistically notable among other variables? Or are there genetic markers that make certain immune systems more effective across the board, meaning a person doesn’t get sick often, doesn’t have auto immune diseases, and also doesn’t get cancer?

The data to answer such questions would ideally control for demographic factors like age, poverty level, etc. and self-reported behaviors related to a healthy lifestyle. I recognize this is a pipe dream in terms of scientifically validated data but I am looking for any evidence that attempts to answer this question.

Thank you, that’s helpful. It sounds like it’s too complex and individualized for us to have answers beyond generalizations at this stage of scientific knowledge.

But not all immune systems are alike or normal, so what makes for those that are less effective, in the sense that the person gets actually sick more often? (Again, other variables like diet and exercise and sleep and age being equalized if possible - looking for info from scientific studies)

This is helpful, and makes it sound like genetics have the greatest impact on the effectiveness of an immune system in context…

Sure, that makes sense. That’s what I’m interested in—not outward symptoms of being sick but the immune system’s effectiveness against viruses and bacteria.

Wouldn’t a strong immune system be one that responds appropriately in the 5 ways you listed?

In that case I’m most interested in what determines the health / effectiveness of each of those distinct systems

I think they meant a small amount on a population level, not on an individual organism level. And on a population level, a small amount of Neanderthal mdna carriers would indeed be easy to lose to history because they would have to have had an unbroken line of daughters leading to today, any carriers who only had sons would break the line, as others explained above. Thousands of years alone is plenty of time for that to occur, if the Neanderthal mdna female homo sapien population was small to begin with.

It’s junk science to say definitively “ADHD is genetic” with no acknowledgment of the complexity and nuance behind ADHD

New things can be learned about ADHD and it is not proven as 100% genetic. Science is always evolving.