kintleko t1_jbb3csm wrote

Title is misleading. When it comes to sex behavior, for example, hormones absolutely matter. But this study assessed open-field behaviors, what mice generally do to explore their environment. The take-away isn't "hormones don't influence behavior."

The take-away is this:
Instead of using male mice for most general behavior studies, we should consider using females. They have less variability in their exploratory behavior than men, and estrous cycle doesn't seem to influence this particular measurement much. The authors say: "Our findings argue for the inclusion of both sexes in experiments querying behavior and support the perspective that females—rather than males—should be the default sex used in studies of exploratory behavior in circumstances in which both sexes cannot be tested."


kintleko t1_j60fdee wrote

I know it's not popular, but what about exercise? What do you do to stimulate blood flow throughout your body? Do you break up sitting periods with short walks, or other calisthenics? My office is only 62 F, but short walks / pushups / pullups throughout the day keep me warm and focused. (I also wear leg warmers tbh). Just ideas, don't shoot the (exercise) messenger.


kintleko t1_j5zog91 wrote

Are you willing to get on your equipment once a day? Start with your lowest winnable strategy. For example, are you willing to try 1-2 minutes on each piece of equipment?
Forming the habit is not easy, but repetitions are key to making it feel almost automatic. Using you equipment for a minimum amount of time will lead to longer workouts and more challenging ones (when you feel like it), but in the meantime, get those small wins to build momentum. I'm rooting for you!

Start today. Workouts do not need to be arduous to be effective, especially when you are not starting from a super high degree of fitness.


kintleko t1_j48sjok wrote

As we age, some take on more oxidative damage than others. Even DNA shows differences in age-related damage. And some show greater levels of systemic inflammation. A great deal of this depends on modifiable lifestyle factors, so in this paper, the authors note that the same healthy-aging benefits available via diets (rich in fruits and vegetables) may be possible by supplementing plant-based compounds directly.


kintleko t1_j25lepe wrote

I've used window film in many houses/rentals. (I like the foggy-looking kind but also have some striped varieties of window film). Moisture has not been an issue for the film at all, just be sure to apply it to a CLEAN window surface and use a spray bottle (and maybe a squeegee) to get all the air bubbles out upon installation. It can be a pain to trim so be sure to use a sharp razor blade.


kintleko t1_j1zs4rj wrote

Yes! Just like Adam says, the pattern can be bookended from the sink outward. This is what I did, it looks incredible. There is a seam at the center of the sink (I know some folks hate that but a farmhouse would hide the front seam as an option) but then the bookend goes in both directions (granite) for ~10 feet on both sides.


kintleko t1_iydxopu wrote

Interesting question - Parkinson's patients aren't great candidates for amyloid therapies because amyloid deposition doesn't seem to CAUSE Parkinson's symptoms or be associated with brain function deficits in this population. At least not consistently. Amyloid builds up in a lot of people as they age, especially if they have sleep problems, but it doesn't always mean Alzheimer's or a decline in thinking. (For examples of the disconnect between amyloid burden and brain function, see this 2019 study in PD patients)


kintleko t1_iydwacg wrote

It is common knowledge that the amyloid hypothesis only holds water for about 1% of all Alzheimer's disease (AD) patients. Those folks inherit genetic susceptibility factors that cause higher amyloid production or slower amyloid clearance, and they develop AD earlier than sporadic cases. We still routinely use those amyloid-heavy genetic mouse models of Alzheimer's in the lab to test memory effects of different drugs or interventions, so there's still a heavy amyloid basis in research even though it may not apply to most AD cases.