lobster_johnson

lobster_johnson t1_j7qyau4 wrote

Some autoimmune disorders like rheumatoid arthritis and psoriasis are indeed associated with an increased risk of cancer. The link between psoriasis and cancer was considered relatively recently.

A Danish systemic review, Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-analysis (Vaengebjerg et al) made these observations about psoriasis:

> From a total of 112 studies included in the analysis, overall cancer prevalence among persons with psoriasis was 4.78% (95% CI, 4.02%-5.59%). When keratinocyte cancer was excluded from the analysis, the prevalence of overall cancer decreased to 4.06% (95% CI, 3.31%-4.87%). > > From the 14 studies that reported risk estimates in the context of overall cancer or included a reference group, the risk ratio for cancer development in those with psoriasis was 1.21 (95% CI, 1.11-1.33), but decreased to 1.14 (95% CI, 1.04-1.25) when keratinocyte cancer was excluded.

Here is an article summarizing the findings. Lymphomas and skin cancers are among the top cancers seen in among psoriasis patients.

A challenge with these studies is that they often look at people with severe manifestations of the disease, or that are being treated with immunosuppressive drugs such as biologics. The above study tries to account for the latter, but not (if I remember correctly) the former. While I don't have a citation in front of me, the association is mostly with severe psoriasis, not mild psoriasis.

Rheumatoid arthritis is another autoimmune disease tied to cancer. RA patients have double the risk of developing [lymphomas] https://www.arthritis.org/health-wellness/about-arthritis/related-conditions/other-diseases/arthritis-and-cancer-risk in particular.

7

lobster_johnson t1_j048gl6 wrote

"Disjointed" is basically a core element of Hugo Blick's style. If you've watched his previous shows, especially The Shadow Line and The Honourable Woman (both masterpieces), all of the same elements are there.

Blick has a unique style. He draws out the dialogue scenes to absurd extents, he relies on stilted, stylized (some people have called it tarantinoesque) dialogue, and he appears to intentionally undermine moments of action with broken pacing, and violate a dozen filmmaking rules at the same time. Sometimes it feels like we're watching a stage play and not TV. But somehow it seems calculated and somehow it works, and his shows are always beautifully shot and filled with superb character actors.

One of the things I like is the air of mystery he's able to imbue his shows with. Even when the plot is a pretty straight story, you never get too close to the characters to get bored of them. There's always some inexplicable motivations going around.

The nearest contemporary I can think of in terms of style and weirdness is David Lynch, especially the Twin Peaks sequel.

I've not seen all of The English yet, so I will reserve judgement. So far it hasn't grabbed me as much as Blick's earlier shows, but I don't dislike what I've seen so far.

2