Not an expert, but as long as it isn't an clone using the same DNA. There will always be a chance for mutations. Their offspring are near, but not exact. Whatever happens they are gaining males with a Y.

Now if you are thinking of diseases like human inbreeding does. All species do have that problem. They just die off or it's a common problem with XYZ. Humans live longer than their breeding age and they are many, many people. So problematic mutations just stick around and get worse.

I do want to add on to that. A pizza stone and a pizza steel are both real things. With advantages and disadvantages. I have both. Using the stone if I'm making a single pizza and just use the stone as the "serving plate". A pizza steel hold the heat much better than a stone would. Making it better for multiple pizzas and not something you want to serve with.

I have to agree. Honestly, I forget that the dough continues to work itself after you mix everything together. There are a few youtubers that has shown their experiments. Going too far as no yeast, no sugar, etc. I know Adam Ragusea has a series that goes through a lot of different checkboxes. https://www.youtube.com/watch?v=o4ABOKdHEUs