DNA mutations aren’t always a bad thing. Sometimes mutations can offer benefits. Think about evolution. Species evolve thru genetic mutation over generations and generations.

The cells in our body are constantly replicating themselves. During the replication process, DNA is copied and pasted for the new cell. The copying and pasting process doesn’t always go right and sometimes you run into mutations. Aging is a part of this DNA mutation phenomenon. As more things go wrong, your body slows down and becomes weaker. This along with all the physical stress your body goes through on its life.

Engine braking along with brakes would be fastest in theory as it applies the most stopping forces. But humans cannot downshift that fast realistically so realistically, slamming on your brakes and letting ABS do the work is the best choice.