Fructose doesn’t also stimulate the satiety hormones unless it gets converted into glucose first, which only a portion of it does. So you’re hungrier on a fructose diet than a glucose diet.

And a metabolic pathway to process it in the liver can lead to fatty liver disease.

But let’s put it in all our food and drinks.

Imagine the conditions an ancient plant needed to survive in, pre pesticides, pre modern irrigation, pre greenhouse, etc. They had to be a lot more robust in unpredictable conditions. Our current climate is making conditions less predictable again, but our crops were bred for predictability. So we need to help our crops adapt.