Narcan (Naloxone) blocks endorphin receptors, preventing endorphins (your body's natural pain killer - "endogenous morphine") from doing its job. So while it doesn't directly increase pain, it keeps your body from taking its normal steps to *reduce* that pain, leading to greater overall pain perception.
svenx t1_jefg3rf wrote
Reply to What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn
Narcan (Naloxone) blocks endorphin receptors, preventing endorphins (your body's natural pain killer - "endogenous morphine") from doing its job. So while it doesn't directly increase pain, it keeps your body from taking its normal steps to *reduce* that pain, leading to greater overall pain perception.