For me personally, 2012 wasn't that different to now. I had a laptop, a smartphone, spent a lot of time on social media. 2002 on the other hand was a completely different world. We didn't have internet at home at that point.

Seems to me that they’re such small changes, they would be part of the normal dynamics of the protein at room temperature. So they could very easily interconvert. If that’s indeed the case they’re essentially the same thing.