triffid_boy
triffid_boy t1_j7d787t wrote
Reply to comment by ElectronGuru in Vitamin D supplements linked to reduced risk of suicide, study of veterans finds by thebelsnickle1991
Vitamin D should be taken with food with some fat in, but there isn't great evidence saying you should avoid taking vitamin D in the afternoon or evenings. Logically, since you make vitamin D from the sun exposure during the day, natural vitamin D levels are probably highest around noon-2pm.
triffid_boy t1_j7d6njj wrote
Reply to comment by enirgin in Vitamin D supplements linked to reduced risk of suicide, study of veterans finds by thebelsnickle1991
I agree with your post, but There is atleast a difference between low and high doses, with higher doses having the lowest risk.
A dose response relationship is always nice to see.
triffid_boy t1_ixlbujy wrote
Reply to comment by Primary-Signature-17 in If freezing tissue generally damages the cells, how are we able to freeze human eggs and embryos for birthing later? by badblackguy
There's probably no need to specifically watch/screen people born from older embryos. it'll be part of their doctor/patient interactions and there's no real reason to think that stuff stored in liquid/vapour phase of nitrogen would biologically age much at all.
triffid_boy t1_iwp60md wrote
Reply to comment by Chemputer in How do medical researchers obtain lab animals with diseases like specific forms of cancer which arise spontaneously? Do they raise thousands of apes and hope some eventually develop the disease? by userbrn1
I think you missed the point of my comment. The implication from the comment I replied to was the technical challenge of Crispr in primates was limiting factor, I used the example of current, clinical, use in humans of Crispr as an argument that it's not a technical limitation that prevents more widespread research in primates.
triffid_boy t1_iw40zwc wrote
Reply to comment by Cersad in How do medical researchers obtain lab animals with diseases like specific forms of cancer which arise spontaneously? Do they raise thousands of apes and hope some eventually develop the disease? by userbrn1
I mean sure, but you said could feasibly be studied since those recent papers - they were feasible models for a long time now.
triffid_boy t1_iw40t17 wrote
Reply to comment by gwaydms in How do medical researchers obtain lab animals with diseases like specific forms of cancer which arise spontaneously? Do they raise thousands of apes and hope some eventually develop the disease? by userbrn1
Risk is minimal, I didn't say there was a risk concern?
triffid_boy t1_iw3ram7 wrote
Reply to comment by CrateDane in How do medical researchers obtain lab animals with diseases like specific forms of cancer which arise spontaneously? Do they raise thousands of apes and hope some eventually develop the disease? by userbrn1
CCR5 is useful in cold/flu response and that's a hell of a lot more common than HIV. even in people with close contact with someone with HIV. Hell these days colds and flus are more of a faff than HIV is for those people infected but taking PReP!!
It was such a ludicrously ethically dumb experiment.
triffid_boy t1_iw3qvhw wrote
Reply to comment by Cersad in How do medical researchers obtain lab animals with diseases like specific forms of cancer which arise spontaneously? Do they raise thousands of apes and hope some eventually develop the disease? by userbrn1
It's not the technical difficulty, but the ethical difficulty.
Crispr is already in use in patient cells for things such as Car-t therapy. And we are primates.
triffid_boy t1_iw3qo3v wrote
Reply to comment by Chiperoni in How do medical researchers obtain lab animals with diseases like specific forms of cancer which arise spontaneously? Do they raise thousands of apes and hope some eventually develop the disease? by userbrn1
Great explanation. Worth touching on this being a reason that a lot of model animal studies don't always scale well to human.
e.g. P53 knockout mice make lots of tumours, give those mice an antioxidant rich diet and they get fewer tumours. P53 is a major component of the antioxidant pathway, so this shows more about p53 pathway than cancer, really.
triffid_boy t1_ivno6im wrote
Reply to comment by imveganbtvv in Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice (Nov 2022) by basmwklz
The fasting bit has you restricting calories my friend.
triffid_boy t1_ivcexjh wrote
Reply to comment by amitchellcoach in Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice (Nov 2022) by basmwklz
No no just start a blog about intermittent fasting, cite this study and tack on a bit about your new book.
triffid_boy t1_ivceurb wrote
Reply to comment by kvotebloodless in Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice (Nov 2022) by basmwklz
These aren't the only studies that suggest a benefit to CR, and the mechanism - via mTOR - is reasonable.
triffid_boy t1_iu922eo wrote
Reply to comment by EastvsWest in Exercise linked with increased longevity. Compared with just two minutes of vigorous activity per week, 15 minutes was associated with an 18% lower risk of death and a 15% lower likelihood of cardiovascular disease, while 12 minutes was associated with a 17% reduced risk of cancer by Wagamaga
Like I said, I agree with you, and do exactly this.
But that's not the point. bombarding People who aren't already active with a big to do list as a way to get fit is a bad idea. Start with little and often with consistency and build from there.
Your attitude will turn people away from a really important realisation.
triffid_boy t1_iu5oer1 wrote
Reply to comment by EastvsWest in Exercise linked with increased longevity. Compared with just two minutes of vigorous activity per week, 15 minutes was associated with an 18% lower risk of death and a 15% lower likelihood of cardiovascular disease, while 12 minutes was associated with a 17% reduced risk of cancer by Wagamaga
While I agree with you in principle and practice, you've now added your own stuff on top. In doing so you are perfectly demonstrating why information like this doesnt get communicated or gets lost. People add their own stuff to the proven facts all the time.
Keep it simple. A little bit of intense exercise adds up to good health gains. If People take this up they might see improvements and look to make more gains through other means like weights.
triffid_boy t1_itk6tuf wrote
Reply to comment by [deleted] in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
Because all these disease associated genes have functions, we can't just knock them out, they have important work to do. The disease associate variants are just that, a variant of a healthy version of the same gene, which could be all sorts of different things, too much/little expression (Crispr won't do anything here), or a mutation that changes the protein (Crispr might do something here with a lot of additional tinkering).
The other problem is delivery. It's relatively easy in a dish, but doing it to every cell in the body is essentially impossible. If the disease exists in, or can be fixed by modifying, an accessible cell type like say circulating immune cells, then that's the first target for medicine. See for example car-t cells.
triffid_boy t1_itimb7u wrote
Reply to comment by [deleted] in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
Never said it was useless. It's awesome, I use it in the lab. But It's not a cure-all. We can't just "Crispr it" when we identify even a single gene trait genotype caused a certain disease.
triffid_boy t1_itih9pb wrote
Reply to comment by [deleted] in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
No, it causes an indel, which typically knocks out genes. Various modifications to it exist to make use of the cuts to insert a gene, but Crispr is just a technique for cutting DNA in a precise location.
triffid_boy t1_itih0qo wrote
Reply to comment by sfzombie13 in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
A reasonable case is given through the other studies in the paper to be honest, e.g demonstrating that they have similar transcriptomic signatures to post mortem brains with PTSD.
triffid_boy t1_ithkgw0 wrote
Reply to comment by sfzombie13 in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
The studies are not on the people, they're trying to identify genetic targets and generate models to use in vitro. It's completely valid.
triffid_boy t1_ithf908 wrote
Reply to comment by Typical-Technician46 in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
I think your comment explained well enough why you had to leave research.
triffid_boy t1_ithf427 wrote
Reply to comment by [deleted] in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
How would knocking out genes help?
triffid_boy t1_ithf16s wrote
Reply to comment by sfzombie13 in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga
It wouldn't be enough for a medical study, trial or intervention or whatever, but it's a different kind of study. They're not studying people or interventions per se, they're studying the neurons/genetics. Having 39 samples for this seems pretty good. If you're suggesting they should have generated neurons from stem cells from hundreds of people ... Good god man have mercy on the lab people!
triffid_boy t1_is2ko6b wrote
Reply to comment by TheLeakingPen in Meat, vegetables and health — interpreting the evidence: Although questions remain about several diet and disease associations, current evidence supports dietary guidelines to limit red meat and increase vegetable intake. by Meatrition
To be honest I think everyone gets the numbers these days.
Public health has to be based on these sorts of calculations... So obviously (blindingly obviously) 18 people per 100k (what's that, about 18,000 across the whole population?) saved would be a good thing.
triffid_boy t1_j96kqfb wrote
Reply to comment by Amesenator in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz
Maybe but you should assume no, since this has not been tested in the above study.