Progress is going to be massive, but its hard to predict the point when progress slows or completely stalls; and I don’t believe we are certain that AGI is possible. Though I believe it is, still early to tell from what I’ve read. Though perhaps someone closer to the field can chime in.

Mouse models are actually pretty good, and the transplantable tumor models like mc38 are more aggressive than essentially any human cancer. The huge issue with mouse models is people starting the study very early after establishing the tumor in mice, when the tumor is quite weak really.

One of the biggest issues with these papers is how early they start treating tumors - 7 days after graftment?

For these tumor models, you implant the cells on the back of the mice, and they need time to grow and form an actual robust tumor. 7 days is such little time to do all the things a tumor needs to do: teach the immune system to support it/help it, get blood vessels, build strong local environment to support it etc

7 days is not a great starting point… very early … rather see at least 12-14 days… for at least a more accurate model.

Not just a problem for this paper, problem around the field of cancer models in mice - people start early to make the effect look better.